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While it launched initially as a diabetes drug, early studies revealed its effectiveness for weight loss, prompting many health care providers to prescribe it off-label for weight loss
Pancreatitis and gallbladder issues: Severe abdominal pain that radiates to the back, nausea, fever, or vomiting while using GLP-1s may indicate inflammation of the pancreas, while upper right abdominal pain, jaundice, fever, and nausea can be due to gallbladder issues such as gallstones
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In 2022, Medicare gross total spending reached $5.7 billion on Ozempic (semaglutide), Rybelsus (semaglutide), and Mounjaro (tirzepatide), all of which it covered for diabetes that year, according to just-released Medicare drug spending data
A recent review by Gatto et al., published in May 2025, reached a similar conclusionsuggesting that GLP-1 receptor agonists may have a positive impact on musculoskeletal health
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