Sun P, Wang M, Liu YX, Li L, Chai X, Zheng W, et al
The REWIND cardiovascular outcome trial also revealed that dulaglutide administration resulted in inferior ocular outcomes, leading to an increased need for interventions such as photocoagulation, anti-vascular endothelial growth factor (VEGF) therapy, or vitrectomy compared to placebo recipients [38]
However, post-marketing surveillance and patient reports suggest that some individuals taking semaglutide do experience leg cramps during treatment
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Weeks 2-4: Early Effects This window is where the first tangible effects begin separating from placebo