Common adverse effects reported by participants who took the highest dose of retatrutide in the TRIUMPH-1 trial included nausea (42.4% of participants), diarrhoea (32.0% of participants), constipation (26.1% of participants) and vomiting (25.3% of participants)
Oral semaglutide shows weight loss of 1015%, reflecting lower bioavailability
Specialty drugs represent only about 2% of prescriptions but account for roughly half of total pharmacy spending
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In most cases where menstrual changes occur during weight loss, these settle as weight stabilises and the body adapts to its new metabolic state