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These effects were attributed to the activation of the GLP-1, CCK, and PYY hormone cascade triggered by bitter receptor stimulation in the gastrointestinal tract

"It should be used only for short periods to quell acute nausea, not chronically to permit rapid dose escalation

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Most patients report "back to normal" or "new normal" by week 20 to 24

Sci Transl Med (2017) 9(407):eaal4712