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In a randomized, double-blind, placebo-controlled trial, once-weekly exenatide (2 mg) administered for 48 weeks significantly improved motor scores in patients with PD, with benefits sustained even after treatment discontinuation ( Collectively, these findings indicate that incretin mimetics provide neuroprotection extending beyond metabolic regulation by targeting multiple pathogenic processes in PD, including mitochondrial dysfunction, neuroinflammation from oxidative stress, sirtuin dysregulation, insulin resistance, and S toxicity (Figure 2)

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Yancopoulos, MD, Board Co-Chair, President & Chief Scientific Officer Number Of Employees: ~15,400 Stage: Public Financial Snapshot: The companys market cap as of July 2026 was $70.54 billion

Gracia Graells M, Alcolea Lpez JM

Common community options include adding cagrilintide for satiety, adding MOTS-c for mitochondrial support, or adding a GH secretagogue (covered in the Advanced Recomp Stack) for lean mass