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Chou CC, Pan SY, Sheen YJ, Lin JF, Lin CH, Lin HJ, et al
These functional benefits are mediated through convergent intracellular signaling cascades: BDNF activates tropomyosin receptor kinase B (TrkB)-dependent Phosphatidylinositol 3-kinase/Protein kinase B (PI3K/Akt) and Mitogen-activated protein kinase/Extracellular signal-regulated kinase (MAPK/ERK) pathways to enhance survival and synaptic plasticity, reducing apoptosis and preserving retinal structure in hyperglycemic conditions (34, 162, 183)
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Clinical trials show that it lowers HbA1c levels (a measure of long-term blood sugar) and supports weight loss, all while being well-tolerated by patients.[7]
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The placebo effect is a well-described phenomenon, but it never ceases to amaze me
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