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GLP-1 is produced together with anorexigenic peptide GIP, and the combination of the GLP-1R agonist and GIP synergistically reduces the level of feeding and body weight
An exploratory DEXA analysis of the STEP 1 trial found that semaglutide produced a 9.7% reduction in total lean body mass over 68 weeks alongside a 19.3% reduction in total fat mass, meaning fat was lost at roughly twice the rate of lean tissue
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N-terminal acetylated, C-terminal amidated
In professional body cosmetics, it is integrated as support in protocols aimed at improving the appearance of localised fat deposits
The importance of sleep for peptide efficacy is one reason why some practitioners include DSIP in comprehensive recovery protocols
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