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The half-life of retatrutide is estimated at approximately six days based on phase 1 pharmacokinetic data, broadly similar to tirzepatide [2]

Relative to the previous study, the present work used more recent data from two different databases, included two additional CV outcomes (MI and the composite of ischemic stroke and MI), and analyzed two large US databases to ensure adequate representation of the US population with T2D and ASCVD

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and Mallick M.A.: Drug innovation studies targeting Diabetes: A computational docking approach on muti-drug targets including COVID Agonists

Those taking levothyroxine may require thyroid function monitoring, as semaglutide may increase levothyroxine exposure