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As estrogen declines, body-fat distribution shifts from hips and thighs, where fat is relatively protective, to the abdomen, where it becomes visceral fat , the inflammatory type that wraps around internal organs and drives insulin resistance

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Bovilla VR, Kuruburu MG, Bettada VG, Krishnamurthy J, Sukocheva OA, Thimmulappa RK, et al

Decades of effort at last culminated in a drug, semaglutide, that people with diabetes could administer once weekly, unlike multiple daily injections of insulin

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