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While there is no evidence that Rybelsus worsens liver function, the presence of significant hepatic compromise may affect overall clinical stability

BMI measurements are counted at the start of GLP-1 therapy so even people who fall below the threshold now can qualify if they can show they had a high enough BMI when they began taking the drugs

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FDA Drug Safety Communication: PPI Long-Term Use and Fracture Risk

Lyophilized sample in a sterile glass vial

Second, among GLP-1 receptor agonists, only liraglutide and dulaglutide showed increased trends in the risks of overall thyroid disorders compared with placebo and other antidiabetic drugs