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A 2026 retrospective study in The Lancet found that postmenopausal women receiving tirzepatide alongside hormone therapy were more than four times as likely to achieve 30% weight loss compared to those on tirzepatide alone: 18% versus 4%

Side effects and safety considerations Both peptides share a common side-effect profile: injection-site reactions, occasional flushing, transient fluid retention (more common with tesamorelin), and rare arthralgias

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Everyones body reacts differently, so Its essential to consult a healthcare provider thats best for you