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Expert Opin Drug Saf.16, 351-363

This means several things for researchers: First, the safety database is smaller than for approved compounds

Psychiatric adverse reactions, including new or worsening psychosis and triggering of manic episodes in people with bipolar disorder

When lifestyle measures prove insufficient, laxatives may be appropriate: Osmotic laxatives (macrogol/polyethylene glycol preparations) are often considered first-line for chronic constipation

If no irritation occurs after another two weeks, you might consider moving to a 2-3% product

(It appears to be a fragment of a larger gastric protein, but no one has traced it to a human gene