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The short treatment duration becomes a feature rather than a limitation when the weight loss goal is modest

[oai_citation:1PubMed]( 2) Nitric-oxidemediated, largely endothelium-dependent vasorelaxation Aortic ring experiments showed vasodilation that was blunted by L-NAME and hemoglobin and attenuated without endotheliumconsistent with NO-mediated effects

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Combined with adequate water intake and fiber supplementation , this three-pronged approach addresses constipation from multiple angles simultaneously