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Where Cannabis Enters the Conversation Cannabis interacts with the endocannabinoid system (ECS), a regulatory system that influences: Appetite Metabolism Mood Sleep Inflammation The ECS includes cannabinoid receptors throughout the central nervous system, immune system, and peripheral tissues

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However, mechanistic investigations reveal that this advantage varies by individual, underlining the importance of accurate immunophenotyping to predict who may benefit from cytokine-targeted therapy

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