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Together, these findings suggest that ferroptosis contributes to HD pathology, and its inhibition may represent a viable strategy for disease modification ( Figure 9 )

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Por1 couples the glutathione pools of the IMS and the cytosol The cytosol and IMS are separated by the OMM, which contains porins as the major gateways for the exchange of small molecules

Du Q, Yuan S, Zhao S, Fu D, Chen Y, Zhou Y, et al

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Hydroxycarbamide versus chronic transfusion for maintenance of transcranial Doppler flow velocities in children with sickle cell anaemia-TCD with Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial