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Leptin levels decline during weight loss and signal to the hypothalamus to stimulate feeding, reduce energy expenditure, and promote weight regain

Richard DiMarchi, one of the pioneers of GLP-1 drugs, argues that the degree which they have helped to manage excess body weight compares with the historic breakthroughs in the management of excess blood pressure, excess lipids and excess glucose

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I recommend a combination of magnesium and potassium citrate for best results