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This slow, steady absorption pattern is intentionalit allows the medication to work steadily throughout the week rather than causing sudden spikes
Recent clinical trials demonstrate that these medications achieve unprecedented weight loss results, with Zepbound showing 47% greater relative weight loss compared to Wegovy in head-to-head studies ^2
Primary outcomes included changes in BMI z-score and waist circumference
The main clinical concern is that rapid weight loss may alter how much thyroid hormone your body needs, potentially requiring dose adjustments during the first months of treatment
This distinction matters clinically
Red flags that require medical evaluation A sustained resting heart rate above 100 beats per minute (tachycardia) at rest is never normal and should prompt medical evaluation regardless of the cause
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