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In a multivariate logistic regression model, it was found that the presence or absence of MS was the only independent predictor of endothelial dysfunction (55).The occurrence of endothelial dysfunction represents an initial pathogenic occurrence in the development of MetS

However, various factors can deplete these stores

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588-590 A placebo-controlled crossover trial in 21 healthy middle-aged volunteers found a single dose of 302 mg decaffeinated green coffee extract (but not higher doses) improved blood vessel function up to 24 hours post-dose

PMID 26236730