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A recent human study presented at the Endocrine Society meeting found that obese men treated with GLP1 receptor agonists, including semaglutide, dulaglutide or tirzepatide, experienced a rise in normal testosterone levels from 53 percent to 77 percent over 18 months (closely correlated with weight loss), demonstrating how peptide-based therapies can effectively support and restore healthy testosterone production

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Summarizing we provide a detailed characterization of the interaction of p53 with FOXO4 and FOXO4-DRI which is the basis for development of p53 inhibitors to treat diseases linked to cellular senescence such as cancers

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