Hydroxocobalamin, the form most commonly used in the UK, may cause: Injection site reactions (pain, redness, or swelling) Temporary reddish discolouration of urine Rarely, hypersensitivity reactions Very rarely, hypokalaemia in severely deficient patients when treatment is initiated (potassium levels should be monitored in severe deficiency) B12 injections are considered very safe, with no upper tolerable limit established, as excess B12 is excreted in urine
Hydroxocobalamin Attaches well to transport proteins, but some may convert to inactive forms
The significance of this finding for the clinical management of these patients is also becoming clearer
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Methylcobalamin is the biologically active form
Unfortunately, you can push your muscles to failure and eat all the protein in the world