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Farnesoid X receptor activation by the novel agonist TC-100 (3, 7, 11-Trihydroxy-6-ethyl-5-cholan-24-oic Acid) preserves the intestinal barrier integrity and promotes intestinal microbial reshaping in a mouse model of obstructed bile acid flow
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Journal reference: W
Key Takeaway: Mechanistic potency in a petri dish does not equate to clinical relevance
Lucaci AG, Notaras MJ, Kosakovsky Pond SL, Colak D (2022) The evolution of BDNF is defined by strict purifying selection and prodomain spatial coevolution, but what does it mean for human brain disease
And getting either one wrong means wasted money, wasted peptide, or both
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