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10.1016/j.ejphar.2019.01.030 106 SeverM.KlicekR.RadicB.BrcicL.ZoricicI.DrmicD.et al (2009)

The vitamin is also essential for DNA synthesis and red blood cell formation, meaning deficiency can have wide-ranging effects beyond the nervous system, including fatigue and cognitive difficulties

When youre deficient in B12, not only do the nerves suffer but the body also struggles to produce sufficient healthy red blood cells to carry oxygen to tissues and nerves, compounding the problem and often leading to anemia

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Temperature differences can affect how the powder dissolves