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Behzadi P, Garca-Perdomo HA, Karpiski TM

Ferreira et al., 2021

Despite adequate membrane permeability, this low solubility places luteolin within a Biopharmaceutics Classification System (BCS) class IItype compound, where dissolution (not permeability) is the primary barrier to oral uptake (Chen et al., 2022)

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In addition, several other targets unrelated to CBS have been suggested by later studies ( CSE CSE is another PLP-dependent enzyme in the transsulfuration pathway