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This weakens immune function and allows toxins to build up in the body, resulting in toxic overload, disease, and premature aging
doi: 10.1017/s204579601700052x 14 MaliskaMTrdzborBKrzystanekM
Nature 600 , 408418 (2021)
In hypoxic zones, HIF-1 directly regulates the function and differentiation of MDSCs, and such tumor-derived MDSCs are more immunosuppressive compared with splenic MDSCs