"The most common of those would be nausea and vomiting and some facial flushing." The TGA says users could also see a change in the size and pigmentation of existing moles, and an increase in new ones
10.1093/bioinformatics/bts310 136 WalshK
I agree with your comments but this class of drugs must be doing more than slowing digestion
This body of data makes orforglipron the currently best-documented oral GLP-1 substance
The 0.25 mg dose is usually used as a starting dose, followed by an increase to 0.5 mg based on tolerance and clinical response
GLP-1s are highly effective at controlling blood sugar and slowing down gastric processes, but they are also highly effective (so to speak) at bringing on side effects like constipation, nausea, and abdominal pain that, if untreated, will impact adherence and, in turn, short and long term results