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Due to their impact on cell proliferation, glucose metabolism, and hormonal signaling, certain individuals face increased risk when using IGF-1especially in unsupervised or high-dose protocols

Additionally, curcumin exhibits significant anti-inflammatory properties by downregulating microglial activation, reducing proinflammatory cytokines, and attenuating TLR4/MyD88/NF-B signaling cascade after TBI (Xie et al., 2014

PMCID: PMC11357423

If you have diabetes and take insulin or sulfonylureas, monitor your blood glucose levels carefully and discuss medication adjustments with your healthcare provider, as reduced food intake may increase hypoglycaemia risk

These patterns warrant discussion with your GP, who can assess for underlying conditions such as diabetes, thyroid disorders, or other metabolic abnormalities through appropriate investigations

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