10.1136/ard.2006.054593 Summary Keywords glutathione peroxidase-3, activity, inflammation, antineutrophil cytoplasmic antibody, vasculitis Citation Chung J, Ha JW, Park Y-B and Lee S-W (2025) Serum glutathione peroxidase-3 concentration at diagnosis as a biomarker for assessing disease activity and damage of antineutrophil cytoplasmic antibody-associated vasculitis at diagnosis
Why Does This Happen
To explore this idea, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumours) 26 with an uninduced Gclc f/f Rosa26 creERT2 mouse 27 in which the rate-limiting step in GSH synthesis, the glutamatecysteine ligase catalytic subunit (GCLC), can be knocked out throughout the body after induction with tamoxifen
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In anemia, tissues receive less oxygen, causing fatigue and weakness