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To investigate the underlying mechanism, the authors performed untargeted LC-MS/MS metabolomics on serum from these PDAC-bearing mice and observed a depletion of TMAO (microbiota-host, Box 1) upon antibiotic treatment 22
PLoS One 2011
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Tirzepatide was also superior to semaglutide in terms of weight loss, with mean reductions in body weight of -7.6 kg, -9.3 kg, and -11.2 kg for tirzepatide doses of 5 mg, 10 mg, and 15 mg, respectively, compared to -5.7 kg with semaglutide
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