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Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)

If serum free copper rises above 25 mcg/dL, discontinue and reassess [2]

The injection is now ready to be given Step 14

One major limitation of our current understanding is the lack of large intervention studies, as the available insights are mainly deduced from trials enrolling fewer than 100 patients, necessitating the attempt to conduct meta-analyses on results from not always fully comparable trials

Sallach, G

Aims Environ