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doi: 10.1038/s41420-023-01452-8 78 AnXZhangYCaoYChenJQinHYangL

However, a one-year randomized, double-blind, placebo-controlled trial in 253 elderly (65 years) adults with elevated homocysteine levels found that B vitamin supplementation (1,000 g/day of folate, 10 mg/day of vitamin B 6 , and 500 g/day of vitamin B 12 ) did not improve measures of cognitive function, including memory, despite lowering homocysteine levels (116)

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FDA registration trials for brand-name GLP-1 medications showed average weight loss of 1015% of body weight over 68 weeks