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88 A 16-week crossover trial in 36 women did not show any differences between hops (providing 100 mcg of 8-prenylnaringenin per day) and placebo in reducing menopausal symptoms after the first eight-week phase, but women assigned to placebo in the first phase and hops in the second phase had greater symptom relief at week 16 than those assigned to hops followed by placebo, indicating a strong placebo effect and a possible benefit from hops

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Loading regimens involve 1 mg three times weekly for two weeks, or alternate-day dosing if neurological symptoms are present

Sleep quality, mental clarity, and stress tolerance shift first

Athletes and people exercising outdoors round out the picture

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