Currently, many guidelines and recommendations encourage the use of anti-obese medications to achieve this goal (11, 12)
GLP-1 treatment addresses the insulin resistance component directly, which is often the primary metabolic driver of perimenopausal weight gain
Strength training is recommended twice a week to maintain muscle
The medication has also shown some notable effects in obese individuals when used together with exercise and a strict diet
long-term discontinuation data are still emerging from Phase 3 TRIUMPH trials
Clinically, elevated levels of endogenous GLP-1 have been observed in patients with sepsis (6.35-fold increase), end-stage renal disease (4.46-fold), and burns (2.96-fold), indicating a common physiological response to critical illness (Lebherz et al., 2017)