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doi: 10.1056/NEJM199503093321001 32 RosenbaumMHirschJGallagherDALeibelRL

When a persons vitamin B12 blood levels return to normal, they may be able to discontinue taking Cyanocobalamin if they are taking the supplement

Commonly reported side effects include injection-site irritation, headache, fatigue, and mild gastrointestinal discomfort

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Most patients notice early changes within 4 to 8 weeks, with more meaningful improvements in pain and function between 3 and 6 months