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The standard tirzepatide protocol follows a gradual increase designed to minimize gastrointestinal side effects while reaching therapeutic doses

It has been speculated that glucagon also enhances gluconeogenesis in the gut and kidney as both organs possess GCGRs [74] and are believed to generate glucose through processes similar to those in the liver

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10.1038/35101544 67 ShiM.MaiqueJ.ShepardS.LiP.SeliO.MoeO