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Glutathione modulates the production of pro-inflammatory cytokines and chemokines, which helps control inflammatory responses

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GIP Gastric inhibitory peptide

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Besides the well-known targets such as the inhibition of the mTOR signaling pathway, several additional metformin and phenformin targets (e.g., mGPDH, ATF3, STAT3, GSK3, cyclins) have been identified in other cancers (Thakur et al., 2019)