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Some patients experience what they describe as a plateau

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If this occurs: Allow additional time at room temperature (up to 30 minutes total) Very brief, gentle vortexing (35 seconds) as a last resort If aggregation persists, consider re-solubilizing in 10 mM HCl at a slightly lower concentration 6

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If semaglutide is discontinued and blood glucose is not controlled on diet and exercise alone, insulin therapy should be considered