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Once rats achieved stable sucrose-motivated behavior on PR (at 9 weeks of age), AAV-expressing GFP (AAV-GFP) or the GLP-1R shRNA (AAV-GLP-1R-shRNA) was infused bilaterally into the LH (0.5 l per hemisphere during 5 min)

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Key genetic variants like GIPR rs1800437 and FTO rs9939609, and MC4R rs17782313 influence how your body processes GLP-1 signals and manages weight

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