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Tyr 10 and Ile 12 are also used in tirzepatide

As shown in Table 1 , inhibitors or antagonists of these targets have shown good results in animals, such as CXCR3, CXCR4, CXCL10, CXCL12, and CXCL13, especially the antibody of CXCL10 (MDX-1100) has entered clinical trials ( ( Figure 2 )

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The combination therapy group had greater reductions in systolic blood pressure and diastolic BP compared with semaglutide and cagrilintide

Gao et al., 2018

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