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The pathophysiology of neuropathic pain varies and includes ectopic activity in damaged nerves or in adjacent nerves, dorsal root ganglion (DRG) or central pathways, and peripheral and central sensitisation involving numerous molecular mechanisms

Oral doses of 510mg/kg in rodent studies achieve measurable CNS concentrations within 30 minutes, with a plasma half-life of approximately 34 hours and brain tissue half-life extending to 68 hours due to lipophilic partitioning into neural membranes

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Certain compounds discussed may not be approved medicines registered with the Thai FDA for specific therapeutic indications