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Temporizacin de la sinergia: Como los dos pptidos tienen vidas medias diferentes (30 min vs 2h), la co-administracin produce una ventana sostenida de liberacin de GH durante el periodo de activacin receptorial solapada, con pico 15-30 minutos tras la inyeccin

The K7M2 cells were maintained in DMEM, also supplemented with 10% FBS and 1% P/S

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Addgene, 74450) was used for flow-based degradation assays

Ubiquitination activity was dependent on a critical cysteine residue (C18) within the TRIM37 RING domain, 43 as TRIM37 C18R failed to catalyze TRIM28 ubiquitination in E