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Intriguingly, in our study, we observed that TIR treatment prevented the HG induced mRNA and protein downregulation of GLUT3 along with GLUT1, GLUT4, and SORBS1, a protein that takes part in diabetes pathogenesis [31], and regulates GLUT4 translocation [32] affecting neuronal insulin resistance [63]
Healthcare providers often evaluate possible interactions, patient health status, and monitoring needs before recommending this combination
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