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Phase 3: Expanding the Evidence Base Following encouraging Phase 2 findings, retatrutide advanced into the extensive TRIUMPH Phase 3 clinical program , one of the largest research initiatives ever undertaken for an investigational metabolic peptide

The concern about hypoglycemia is more acute during the first several weeks of combining both compounds, before the body equilibrates to the combined glucose-lowering load

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The Nourish report found that in just six months, 64% of patients who combined GLP-1 therapy with nutrition counseling lost at least 5% of their body weight, and 30% lost 10% or more

4 Challenges and future directions 4.1 Safety considerations The safety profile of dual or triple receptor agonists targeting GLP-1, GIP, and GCG receptors in the treatment of MASLD and related metabolic disorders warrants careful evaluation