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The shift in 2025 and 2026 is that two oral GLP-1 options have entered the market for weight loss
The result was largely driven by one large cohort, and neither study reported specific urinary malformation subtypes, limiting causal interpretation
Millions of people who could not get brand-name semaglutide found alternatives through compounding
Adverse Reactions Clinical Trials Experience Transient nausea and vomiting have been observed
The most likely explanation is that semaglutide side effects, particularly dehydration from GI symptoms , indirectly increase clot risk in some users, while the drug direct anti-platelet and anti-inflammatory effects provide protection in others
Diabetes Ther 6 , 239256 (2015)
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