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The extraordinary potency of Dihexa was demonstrated in scopolamine-induced cognitive deficit models in rats (Benoist et al., published in the Journal of Pharmacology and Experimental Therapeutics, 2011)

Doxorubicin is a chemotherapy drug notorious for damaging heart muscle

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Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis

The design integrates several key components, as outlined below: the chosen CBBBP is Tat, identified through prior animal experimentation from two candidate peptides for its superior efficacy in facilitating the transport of therapeutic agents crossing BBB

It might be used alone, or together with a drug such as allopurinol or febuxostat in patients who otherwise could not have their uric acid level brought below 6