Additionally, we find that the decrease in glutamate brought by acivicin could be rescued by administration of pyroglutamate (5-oxoproline), a downstream metabolite in the glutathione pathway that is a precursor of glutamate (Fig
Thus, interfering with these mechanisms and restricting amino acid access holds potential as an anticancer strategy 1
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While B12 is naturally found in animal-based foods, some individuals may struggle to absorb enough of it through their diet alone