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doi: 10.3389/fimmu.2026.1761421 Received 05 December 2025 Revised 31 January 2026 Accepted 04 February 2026 Published 24 February 2026 Volume 17 - 2026 Edited by Qiushui He, University of Turku, Finland Reviewed by Jan Josef Stepan, Charles University, Czechia Namrata Anand, University of Chicago Medical Center, United States Updates Copyright 2026 Liu, Lu, Bai, Han, Zha and Jiang

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Patients who already have exceptionally high pyridoxine levels or signs of pyridoxine toxicity (such as sensory neuropathy) should not continue to receive high-dose supplementation until those symptoms resolve