and Ochoa Gautier, J.B
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Meta-analyses of berberine trials show modest reductions in hemoglobin A1c (approximately 0.5-0.7%) and fasting glucose, with variable effects on body weight, though many studies have methodological limitations and high heterogeneity
A dedicated prospective trial comparing a combined therapy versus either monotherapy is ongoing (PRECIDENTD)
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265,266 Similarly, the newly identified lncRNA -cell function and apoptosis regulator (Faar) ameliorates obesity-associated -cell dysfunction and apoptosis by upregulating the islet-specific genes ( Ins2 , NeuroD1 , and Creb1 ) by sponging miR-138-5p
