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Phosphodiesterase-5 (PDE-5) inhibitors, such as sildenafil (Viagra), have also been linked to a higher risk of NAION

The mechanisms are complementary

Future translational efforts should pursue several directions: first, conducting deep-phenotyping trials in biopsy-confirmed MASH patients, using positron emission tomography to quantify hepatic glucose uptake and correlating these findings with intrahepatic insulin signaling (e.g., p-AKT)

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