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But they are also dose-dependent and temporary
Phospholipase A2 is overactivated during SAP, destroying pulmonary surfactant and inducing inflammation through accumulation of eicosanoids and platelet-activating factor [105]
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High concentrations of 4HNE have been associated with different processes such as apoptosis, cell differentiation, altered gene expression and with several diseases correlated to redox imbalance such as neurodegenerative and cardiovascular diseases, metabolic syndrome, and cancer 15
