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Free fatty acids act on receptors including GPR 43, GPR119 and GPR 120, and FFAR (29, 51, 113), and proteins may act through the Ca 2+ sensing receptor (CaSR) which responds to amino acids (24) or the peptide transporter PepT1 (69)

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Once complexed with Cu(II), the peptide backbone rearranges into a specific square-planar coordination around the copper ion, with donor atoms from the glycine amino terminus, the deprotonated amide nitrogen, the histidine imidazole, and a fourth position (carboxylate or water depending on pH)